In vivo pharmacokinetics

1. Mouse/rat/guinea pig/rabbit/dog/miniature pig/crab-eating monkey

1) Intravenous/subcutaneous/transdermal/muscular/abdominal/oral/sublingual/nasal/vitreous/internal injection

2) Venous cannula/infusion pump/biliary cannula

3) Multi-cycle cross-BE/prescription screening

4) Excretion study/identification of metabolites in vivo

5) PK/PD of tumor-bearing mice

6) Liver biopsy guided by B-ultrasound in monkeys/dogs in large animals

7) Cassette drug administration/continuous micro-blood collection

8) Tissue distribution/blood-brain barrier permeability Kp,uu (in vivo)

9) Drug interactions in vivo

10) 125/14C3H labeled isotope drug PK/ Tissue distribution/material balance

11) Monkey/dog muscle biopsy in large animals

12) Quick screening